The genetics of common epilepsies: common or distinct?
نویسندگان
چکیده
منابع مشابه
The genetics of common epilepsies: common or distinct?
1 Dodick DW, Goadsby PJ, Spierings ELH, Scherer JC, Sweeney SP, Grayzel DS. Safety and effi cacy of LY2951742, a monoclonal antibody to calcitonin gene-related peptide, for the prevention of migraine: a phase 2, randomised, double-blind, placebo-controlled study Lancet Neurol 2014; published online Aug 11. http://dx.doi.org/10.1016/S1474-4422(14)70128-0. 2 Goadsby PJ, Edvinsson L, Ekman R. Rele...
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15 صفحه اولGenetic dissection of the common epilepsies.
PURPOSE OF REVIEW Only two functionally validated susceptibility genes, CACNA1H and GABRD, have so far been identified in the common epilepsies using a candidate gene approach. The difficulty with the alternative statistical approach, where none of the suggested candidates has been functionally validated, may partly be due to the posited genetic architecture of the common epilepsies, such as th...
متن کاملThe genetics of epilepsies.
OBJECTIVES To discuss some of the clinical and molecular genetic aspects of new discoveries in the field of the genetics of the epilepsies and relate these with relevant clues for a better understanding of the mechanisms underlying some of the monogenic epilepsy syndromes. SOURCES Many study designs have been performed over the years and these include family-based studies, genetic-epidemiolog...
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Genetics is a huge and growing area across human biology and medicine, providing information about basic processes from birth to death, from development to degeneration, and in some instances revealing enough about disease biology to lead to rational new therapies or better use of existing treatments. There is much hope that the power of genetics to provide insights into how diseases start and ...
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ژورنال
عنوان ژورنال: The Lancet Neurology
سال: 2014
ISSN: 1474-4422
DOI: 10.1016/s1474-4422(14)70124-3